An explosion at a petrol station in Italy has killed two people and injured several others, according to reports.

The incident occurred as a fuel tanker was offloading fuel at the service station, Rieti police chief Antonio Mannoni told the ANSA news agency.

Smoke billows in the area where an explosion occurred at a petrol station in Borgo Quinzio, near Rieti, ItalySmoke billows in Borgo Quinzio, near Rieti (Emiliano Grillotti/ANSA via AP)

Fire crews were responding to an initial blaze when a huge explosion rattled the area.

The blast occurred along the Salaria state road, one of the main roads north of Rome.